The exact influence of JAK inhibitors on the pathogenesis of LPP/FFA has not been elucidated; however, a recent research study demonstrated that IFN-γ enhanced cell-mediated cytotoxicity against keratinocytes via JAK2/STAT1 in lichen planus, supporting the idea that JAK inhibitors hold promise as therapeutic agents in LPP/FFA [226]. This evidence concerns the gene JAK2 and lichen planopilaris.