Among the genes already described in MDS with germline origin, the following can be highlighted: transcriptional regulators such as CEBPA, RUNX1, ETV6, and GATA2; telomerase regulators TERC/TERT and splicing and signal transduction controllers SAMD9/SAMD9L, RAS/MAPK, and DDX41; kinase signal regulators like ANKRD26; and protein translocation and processing regulators like SRP72 [3,4,5,6,7]. This evidence concerns the gene SRP72 and myelodysplastic syndrome.