For AD-relevant genes, those linked to synaptic function and neuronal plasticity had 21 down-regulated and 21 up-regulated; those linked to signaling of calcium had 14 down-regulated and 14 up-regulated; those linked to phosphatidylinositol (PI) had 7 down-regulated and 13 up-regulated; and for those linked to insulin, the data set had 6 genes down-regulated and 13 up-regulated. The gene discussed is INS; the disease is Alzheimer disease.