That was seen by Baker et al., who studied non-seriously obese (body mass index = 27) subjects with pre-diabetes or diabetes and found that those with greater insulin resistance had an AD-like pattern of reduced cerebral metabolic rate of glucose in their frontal, temporal-parietal, and cingulate regions, that was independent of the subjects’ age, 2-h plasma glucose concentration, or APOE ε4 allele status [21]; and their pre-diabetic or diabetic subjects recalled fewer items on the delayed memory test than their normal controls. The gene discussed is APOE; the disease is Alzheimer disease.