Our study provides the basis for developing a heuristic model that must be incremented by adding, in future studies, other imaging modalities, with a more detailed cognitive battery, to examine whether a similar pattern of hippocampal or anterior thalamic shrinkage observed in AD and KS is associated with similar or different profiles of alterations, including but not limited to, episodic memory components, structural and functional connectivity, metabolism, amyloid and tau deposition. The gene discussed is MAPT; the disease is Alzheimer disease.