To assess the involvement of IL-1β and IL-18 in intestinal lesions of BD, we performed IHC staining of biopsy samples from intestinal lesions using an anti-IL-1β antibody and an anti-IL-18 antibody in eight patients with intestinal BD (four patients with MEFV gene mutations, four patients without MEFV gene mutations) (Figure 2 and Supplementary Figure S1). This evidence concerns the gene IL18 and Behcet disease.