GLP1R and Atrophy: Furthermore, recent experimental studies have illustrated that a GLP-1 receptor agonist liraglutide administration increased citrate synthase activity and Cox5B expression, which represent mitochondrial content and are implicated in the regulation of muscle quality and volume in soleus muscle of spontaneously diabetic torii fatty rats [22], and that another GLP-1 receptor agonist exendin-4 ameliorated muscle atrophy by suppressing muscle atrophic factors and enhancing myogenic factors in a dexamethasone-induced mouse muscle atrophy model [23].