Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy caused by a severe functional deficiency in a disintegrin and metalloprotease with thrombospondin type I repeats-13 (ADAMTS13), the specific von Willebrand factor (VWF)-cleaving protease [1]. This evidence concerns the gene ADAMTS13 and thrombotic thrombocytopenic purpura.