Mutations in the p62 gene have been linked to diverse human diseases such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FD), neurodegeneration with ataxia and also distal myopathy with rimmed vacuoles and Paget disease of the bone [102,103,104,105,106]. The gene discussed is SQSTM1; the disease is amyotrophic lateral sclerosis.