Prompted by these observations, Olivé and colleagues [167] examined and first reported in 2008 the presence of p62 and UBB + 1, a mutant form of ubiquitin B known to accumulate in neurodegenerative disorders such as Alzheimer’s and Huntington’s disease, in a cohort of myotilinopathy and desminopathy patients. This evidence concerns the gene SQSTM1 and Distal myotilinopathy.