The analysis of p62-positive aggregates in the myocardium showed a high prevalence of diffused p62-positive aggregates in phospholamban (PNL) and desmin-related (DRC) cardiomyopathy patients [193], confirming earlier findings in a mouse model of DRC desmin mutant and impaired lysosomal function [194]. The gene discussed is PLN; the disease is cardiomyopathy.