In obesity, the fat storage overload imposes an increased metabolic burden in adipocytes, consequently inducing a state of chronic inflammation, the release of transcription factors (e.g., NFκB, STAT3, HIF1α) and inflammatory cytokines (e.g., TNFα, Il-6, Il-8), subsequently leading to oxidative stress in breast fat tissue [85,110]. This evidence concerns the gene IL6 and obesity due to melanocortin 4 receptor deficiency.