The latter plays a protective role in the development of osteoporosis by indirectly inhibiting osteoclast activity via increasing the activity of osteoblasts and suppressing the effects of proinflammatory cytokines: interleukins (IL-1 and IL-6), tumor necrosis factor alpha (TNF-α), and macrophage colony-stimulating factor (M-CSF) [12]. Here, TNF is linked to osteoporosis.