In animal models of both alcoholic and non-alcoholic steatohepatitis, exogenous adiponectin reduces hepatomegaly, depletes lipid accumulation, quenches hepatic inflammation, and decreases hepatic expression and plasma concentrations of TNFα, thus suggesting that adiponectin may counteract hepatic lipid accumulation through the antagonism of TNFα [73]. This evidence concerns the gene ADIPOQ and metabolic dysfunction-associated steatohepatitis.