RNASE3 and Nasal polyposis: Furthermore, an increased level of anti-DNA double-stranded (anti-dsDNA) IgG in nasal polyp tissues is associated with IgE and eosinophilic cationic protein (ECP), representing more severe CRSwNP phenotypes, such as aspirin-exacerbated respiratory disease or aggressive CRSwNP [5,6,8,9].