Activation of TLR4 promotes the production of vascular endothelial-derived growth factor (VEGF) [129] and contributes to the remodeling of nasal polyps, while TLR3 activation induces the production of type I interferon and TSLP, exacerbating the type 2 immune response and promoting airway epithelial inflammation [130,131]. Here, TLR4 is linked to Nasal polyposis.