Cho et al. found that LPS triggers the immune response through TLR4, activating MAPK and PI3K/Akt signaling pathway and promoting the production and expression of IL-6, IL-8, and MMP-1 in nasal polypus-derived fibroblasts and nasal polyp tissues (Figure 2B) [128]. The gene discussed is TLR4; the disease is nasal cavity polyp.