Furthermore, an increased level of anti-DNA double-stranded (anti-dsDNA) IgG in nasal polyp tissues is associated with IgE and eosinophilic cationic protein (ECP), representing more severe CRSwNP phenotypes, such as aspirin-exacerbated respiratory disease or aggressive CRSwNP [5,6,8,9]. The gene discussed is RNASE3; the disease is chronic rhinosinusitis with nasal polyps.