Now that the role of Peli1 in DDR is known and as Bcl6 sustains the lymphoma phenotype and enables tumor cells to be survived by modulating the DNA damage repair process [195,196], the underlying mechanism of Peli1 to deteriorate B cell lymphoma by activating Bcl6 is possibly associated with DNA damage repair process. The gene discussed is BCL6; the disease is B-cell non-Hodgkin lymphoma.