In mice, overexpression of Peli1 stabilizes Bcl6 resulting in B cell lymphomagenesis, and in diffuse large B cell lymphoma (DLBCL) patients, poor prognosis is followed by a higher level of Peli1 and Bcl6, indicating that Peli1 is a novel oncogenic signal in B cell lymphoma [175]. The gene discussed is BCL6; the disease is diffuse large B-cell lymphoma.