In addition, PL/ACC NPs provided an effective method to target hair follicles, delivered TFC in CYP-induced Alopecia areata mouse model, antagonized the inflammatory factor IFN-γ on inducing the collapse of immune immunity in hair follicles, and down-regulated the expression of MHC II molecules and the number of NKG2D+CD8+ cytotoxic T cells to inhibit apoptosis of hair follicles. Here, IFNG is linked to alopecia areata.