Notably, prior to adjusting for multiple testing, a significant negative association between insomnia severity and serum resistin levels (b = −0.030; 95% confidence interval (CI) [−0.051, −0.009]; β = −0.186; unadjusted p = 0.006; adjusted p = 0.151; R2 = 0.035) and a significant positive association been insomnia severity and serum acetyl-L-carnitine levels (b = 0.039; 95% CI [.010, 0.068]; β = 0.178; unadjusted p = 0.009; adjusted p = 0.151; R2 = 0.032) were observed. The gene discussed is RETN; the disease is insomnia.