Conversely to psoriasis, HS keratinocytes exhibited a significant lower level of VEGF, as well as IL-1α and IL-22 compared to normal keratinocytes using an in vitro scratch assay, which suggests that changes in VEGF signaling may be associated with HS pathogenesis [190,191] (Table 1). The gene discussed is VEGFA; the disease is histiocytic sarcoma.