On the other hand, KLK12 (3.8-fold), KLK14 (3.4-fold), and KLK11 (2.8-fold) were predominantly expressed in the cases negative for lymph node metastasis (pN0), while KLK7 (0.38-fold), KLK3 (0.38-fold), KLK8 (0.41-fold), KLK6 (0.40-fold) and KLK5 (0.41-fold) were predominantly expressed in cases positive for lymph node metastasis (pN1-3) (Figure 1B). Here, KLK3 is linked to metastatic malignant neoplasm in the lymph nodes.