Somatic PSEN1 mutations (such as Ala246Val, Glu71Lys and Arg269Cys) appeared in six major forms of cancer, including breast carcinoma, non-small cell lung cancer, colorectal adenocarcinoma, glioblastoma, endometrial carcinoma and ovarian tumors. The gene discussed is PSEN1; the disease is glioblastoma.