Genetic alterations located in the retinoblastoma (RB1) (chromosome 13q14.2) and TP53 (chromosome 17p13.1) genes cause inactivation of the RB1 and p53 proteins, and are significant genomic modifications involved in osteosarcomagenesis, which may also contribute to metastatic disease. This evidence concerns the gene TP53 and metastatic neoplasm.