Altogether, the above prompted us to determine the association of BCR with its molecular drivers, i.e., to identify functional biomarkers of pivotal relevance in EMT with regards to clinical parameters such as PSA, GGS, and T score to assess the risk of BCR at the time of primary treatment and enable the stratification of the potential for a more aggressive course of PC. This evidence concerns the gene BCR and pachyonychia congenita.