In the present study, we thus evaluated the preoperative prognostic ability of hormonal receptor profiling (AR, ESR1, ESR2, and PGR) accompanied by the other functional markers that play a pivotal role in the mechanism of tumor recurrence (CDH1, VIM, MMP2, MMP3, MMP9, and CTNNB1) and PRAD management (KLK2, KLK3, FOLH1, NR3C1, and preoperative PSA serum level) with BCR by applying the cutpoint optimization algorithm. Here, ESR2 is linked to neoplasm.