Finally, we were able to cross-validate the findings with the independent cohort of Rubicz et al. [31] showing a similar trend of an EMT shift towards the mesenchymal state with the heightened expression of ESR1 and MMP3, notably marked according to the stage of PC (localized/locally advanced) and the GGS (Figure 5), which corresponded to our conclusions and proved the accuracy of the study. The gene discussed is ESR1; the disease is pachyonychia congenita.