The most essential discovery of this study, and at the same time the major conclusion that may be drawn from it regarding the potential clinical implications, was the case of the PC patients collectively classified in the EAU high-risk group for BCR by any of the clinical determinants, such as PSA ≧20 ng/mL, >T2c, N1, and GGS ≧8, who showed an even poorer prognosis of BCR, with an over two-fold increase in HR when the stratum was present (Figure 2, Table 2). The gene discussed is KLK3; the disease is pachyonychia congenita.