ESR2 and pachyonychia congenita: In previous studies, other important factors affecting the mechanism of PC recurrence and progression (i.e., EMT) were shown, such as age and signaling by steroid hormone receptors (AR, ESR1, ESR2), revolving around the remodeling of the tumor tissue architecture and encouraging more aggressive clinical behavior from PC cells, consequently tipping the odds to favor the establishment of overt PC progression among specific subgroups of patients [2,3].