A wide range of cellular processes, including survival, proliferation, growth, metabolism, angiogenesis, and metastasis, are regulated by the phosphatidylinositol-3-kinase PI3K/AKT/mammalian target of rapamycin (mTOR) signaling pathway, which is overactivated in different cancer types by molecular abnormalities [88,89,90]. This evidence concerns the gene PIK3CD and cancer.