Wang J and his research team illustrated that two enzymes involved in tyrosine metabolism, homogentisate 1,2-dioxygenase (HGD), and glutathione S-transferase zeta 1 (GSTZ1) were downregulated in three renal cancer types (KIRC, KIRP, and KICH) of tissues versus healthy ones. This evidence concerns the gene HGD and renal carcinoma.