In addition to the above-mentioned genes, lower expression of CD22 (regulation of the signals implemented by BCR), STAP1 (BCR downstream-signaling protein 1), and Kelch-like protein 6 (KLHL6), which has a role in BCR signal transduction [65], highlights the remarkable role played by BCR in pSS patients’ SGs. The gene discussed is CD22; the disease is peeling skin syndrome.