In thyroid cancer cells, 1 mM (176 μg/mL) vitamin C showed toxic effects, being reported to inhibit the activity of catalase and SOD in ARO [42,43], or it can lead to formation of a large amount of ROS and cause the cell cycle arrest of human bladder carcinoma T24 cells [44] and Ehrlich carcinoma cells [45,46,47]. This evidence concerns the gene SOD1 and urinary bladder carcinoma.