In non-small cell lung cancer (NSCLC), microRNA-135b (miR-135b) directly targets the 3′-untranslated region (UTR) of the deubiquitinase CYLD, thereby regulating the ubiquitination and activation of NF-κB signaling [98], promoting lung cancer cell proliferation, migration, invasion, anti-apoptosis, and angiogenesis. The gene discussed is NFKB1; the disease is non-small cell lung carcinoma.