HMMR and neoplasm: Moreover, both TNC and CCL2 tumor levels correlated negatively with markers of M1 macrophage status (IL6) and positively with markers of M2 macrophage status (CD168 and Arg1), with a higher correlation of TNC than CCL2 at both 3 and 11 weeks (Figure 6C and Supplementary Figure S5A–C).