However, in the progression of pneumonia, cytokine storms caused by excessive responses of M1-type macrophages and the secretion of excessive cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), interleukin-6 (IL-6), and other factors can be fatal [3,12]. The gene discussed is IL6; the disease is pneumonia.