Most studies examining the interictal period of TNF-α [70,82,83] and IL-6 [64,65,67,70,71,72,82,88,89,90,91] have reported higher levels compared to controls and no change with respect to IL-1β levels [69,72,82,83,84,87].IL-10 levels during attacks in migraine patients have been reduced compared to controls [67,79,83,89,93], but IL-4 levels have been reported less frequently and without certainty. The gene discussed is IL10; the disease is migraine disorder.