In the inflammatory soup model of migraine, the release of IL-1β, IL-18, upregulation of P2X7R, and activation of the NLRP3 inflammasome have been implicated in IL-18/IL-18R-mediated microglial astrocyte crosstalk, and microglial astrocyte gliosis might be associated with migraine-related cognitive impairment [45]. Here, IL18R1 is linked to migraine disorder.