The complementarity of INSR-like COX sequences and INS-like Clostridia sequences were demonstrated using U.V. spectroscopy in Section 2.5 and Section 2.6, and it was then shown that TCR derived from T1DM patients recognized these COX and Clostridia peptides as antigens, providing direct evidence of autoimmunity against both microbes in three sets of patient TCR. Here, INSR is linked to type 1 diabetes mellitus.