Macrophage infiltration was greater in the peritoneal wall and heart in association with the upregulation of TonEBP and inflammatory cytokines induced by 1% NaCl drinking water in the adenine-induced CKD model when compared to adenine-induced CKD without salt loading [50], which was similar to the effects observed in 5/6Nx/NaCl mice. Here, NFAT5 is linked to chronic kidney disease.