In an interesting study that combined CAR-NK and CAR-T cells, NKG2D-specific CAR-NK cells were generated to eliminate the NKG2DL-expressing suppressive MDSCs in TME, to lift the immunosuppression on the GD-2-CAR-T cells, and this approach allowed CAR-T cells gain functionality against the tumor cells [180]. The gene discussed is KLRK1; the disease is neoplasm.