ANXA1 and systemic lupus erythematosus: The first is quantitative reduction of protein expression in relevant cells (i.e., neutrophils in polyangiatis), the second is correlated with post-translational modifications such as deimination occurring in ANXA1 of neutrophil extracellular traps (NETs) in SLE and the third is the formation of autoantibodies that target both ANXA1 and ANXA2.