Fcgr2b-/- mice with onset of lupus (16–24 weeks old) were subcutaneously injected with PBS, or self-antigens (apoptotic bodies) mixed with dexamethasone or Dex-NPs weekly for four consecutive weeks and alteration of kidney histopathology, serum anti-dsDNA antibodies, serum IL-6, serum creatinine and urine protein/creatinine was observed (Figure 9). Here, FCGR2B is linked to systemic lupus erythematosus.