Of interest, Dex-NPs, but not dexamethasone, mediated the expansion of CD3+CD4+Foxp3+ Tregs and CD3+CD4+Foxp3+CD25+ activated Tregs in Fcgr2b-/- lupus-prone mice (Figure 10B, middle and left panel). This evidence concerns the gene FOXP3 and systemic lupus erythematosus.