The authors, on the one hand, on the basis of GWAS data, showed a strong link between the locus rs1799945 (C/G) HFE and the human organism iron status (these were analyzed such serum parameters as levels of the iron, transferrin, ferritin, and saturation of transferrin), on the other hand, using a phenome-wide association study with mendelian randomization (MR-PheWAS analyses), established a substantial influence (causal effect) of the status of iron in organisms at risk of anemia and hypercholesterolemia development [36]. Here, TF is linked to anemia.