Considering our in silico data, several genes of the body immune system (HLA-DRB1, HLA-DRB6, HLA-DRB5) and the extensive pathways related with them associated with the immune responses (MHC protein-involved reactions, immune system process regulation, antigen processing and presentation, etc.)are among the causal factors of hypertension. The gene discussed is HLA-DRB1; the disease is Hypertension.