Interestingly, in the same system, in which Fra-1 overexpression was specifically associated with the MES subtype, Fosl1 is essential for the PN (ProNeural) to MES (MESenchymal) transition, which can be regarded as an EMT-like process, associated with tumor progression and aggressiveness of human glioblastoma [131]. Here, FOSL1 is linked to glioblastoma.