In response to paracrine cues, the EMT transcriptional programs are controlled by six “core EMT-TFs” (SNAI1/SNAIL, SNAI2/SLUG, TWIST1, TWIST2, ZEB1, ZEB2), which act in a partially redundant tumor-specific manner to inhibit the expression of epithelial genes and induce the pro-invasive mesenchymal transcriptional programs (for a recent review, see [10]). Here, SNAI2 is linked to neoplasm.