Furthermore, Mohd-Aris et al. [28] in their review discuss the ability of the outer membrane proteins (OMP) to induce effective cross-species protection against other Vibrio species from the same clade of harveyi like V. alginolyticus and V. parahaemolyticus [40], similar to our results, where the HKB immunized group showed a cross-protection (with no mortalities) against the infections by Vibrio owensii and Vibrio alginolyticus. This evidence concerns the gene OMP and infection.