For example, Kinoshita et al. recently reported that the number of chymase-positive mast cells, as well as chymase gene expression, was increased markedly in carcinoma ex pleomorphic adenoma (CXPA) of the parotid gland when compared to the benign parotid tumor, pleomorphic adenoma (PA) [6]. This evidence concerns the gene CMA1 and benign neoplasm of parotid gland.