IDH2 and cancer: Activation of Nrf2 can participate in cancer cell metabolic processes and regulate multiple metabolism related key target genes, such as the production of NADPH, including the main enzymes catalyzing NADPH synthesis: G6PD, IDH1/IDH2, ME1, and PGD, as well as the regulation of the pentose phosphate pathway (PPP), and involved in the regulation of genes involved in glutathione metabolism and glutamine metabolism, among others [56,57].