We previously described an increase of the 4E-BP2–eIF4E complex and a decrease of the eIF4G–eIF4E “active” complex in the CA1 region compared with the cerebral cortex in cerebral ischemia [20,21] as the potential cause of the different susceptibility of these regions against ischemic-reperfusion injury. The gene discussed is EIF4EBP2; the disease is brain ischemia.