PXN and hepatocellular carcinoma: In addition, the carcinoembryonic splicing factor muscleblind-like-3 (MBNL3) splices the lncRNA-PXN-AS1 transcript containing exon 4 so that the lncRNA-PXN-AS1 transcript binds to the paxillin mRNA 3ʹUTR to avoid paxillin degradation, which increases paxillin expression to promote HCC progression [163].