PXN and central nervous system cancer: Later, as more and more studies showed that the abnormal expression of paxillin was associated with the malignant progression of tumors (Table 1), Chen et al. evaluated the high expression of the paxillin gene and protein in glioma tissue using the immunohistochemical method to contribute to the malignant progression of tumor and proved that the high expression of paxillin is significantly correlated with the malignant degree of glioma [24].