The phosphorylation of paxillin at Tyr 31 and Tyr 118 residues has been reported to activate the RhoA/ROCK pathway to regulate tumor cell migration and invasion [14], while many studies have also shown that the increased phosphorylation of paxillin at Tyr31 and Tyr118 residues is considered a marker of metastasis [3]. The gene discussed is PXN; the disease is neoplasm.