Upregulation of oxidative phosphorylation and electron transport chain pathways through Atp5a1 and downregulation of the inflammatory response, regulation of the actin cytoskeleton and focal adhesion pathways—which, in this case, are related to Fn1—and the downregulation of prostaglandin synthesis and regulation pathways related to Anxa5 must be mentioned with regard to MSC-derived EVs from AD. The gene discussed is ANXA5; the disease is Alzheimer disease.