CX3CR1 and Alzheimer disease: The importance of these results is that the authors proved the beneficial effect of the chemokine in AD models and showed stimulation of neurogenesis to be independent of the receptor CX3CR1, which moved the focus of investigations from neuron-to-glia communication signalling pathways toward the expression levels of BACE in neurons and the production of the sole chemokine C-terminal fragment in these cells [32].