The typical complications of obesity, and, by extension, of adipose tissue, are closely related to chronic inflammation, characterized by proinflammatory molecule secretion by macrophages and adipocytes, such as secretion of interleukin 6 (IL6), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1), and interleukin 1β (IL1β), and activation of nuclear factor κβ (NF-κβ), the master regulator of inflammation [53]. Here, TNF is linked to obesity due to melanocortin 4 receptor deficiency.