A comparison of P2rx7fl/fl mouse with CD4+ T (with CD4-cre)-, myeloid cells (with LySM-Cre)- or airway epithelial cell (with CCT-cre)-specific P2rx7 KO mice revealed a role for CD4+ T cell and myeloid cell P2X7 in the development of acute respiratory distress syndrome [196]. This evidence concerns the gene P2RX7 and acute respiratory distress syndrome.