P2RX7 and bone disorder: P2X7 activation has also been reported to mediate Ca2+ fluxes [276] or stimulate NF-κB [277] in rabbit osteoclasts, and prostaglandin E2 release and cell death in rabbit articular chondrocytes [278], but the role of this receptor in the bone physiology and pathophysiology in rabbits in vivo is yet to be established in contrast to mice and human bone disorders [4].