Familial cases of PD are caused by mutations in the SNCA (PARK1) [89], Parkin (PARK2) [90], DJ-1 (PARK7) [91], PINK1 (PARK6) [92], LRRK2 (PARK8) [93,94], ATP13A2 (PARK9), VPS13C [95,96,97] and GBA [98], all well-established single gene disorders. This evidence concerns the gene PRKN and Parkinson disease.