More recently, other important prognostic and predictive factors, such as androgen receptor expression, response to neoadjuvant therapy, tumor infiltrating lymphocyte and programmed death-ligand 1 (PD-L1) expression, subtypes of triple negative BC, gene mutations and the so-called “integrated cluster” groups, were also included in the WHO classification of BC [1]. The gene discussed is CD274; the disease is breast cancer.