Restoration of mitochondrial metabolism with the NAD precursor nicotinamide riboside (NR) rapidly reduced aortic aneurysm formation in Marfan syndrome mice [85] and in the AngII-infused model in ApoE−/− mice fed with a western diet [86], increasing the expression of PGC-1α and TFAM. This evidence concerns the gene TFAM and Marfan syndrome.