PPARGC1A and acute kidney injury: Healthy proximal tubular cells are rich in mitochondria and express high levels of PGC-1α whose expression is severely reduced in human AKI and in preclinical AKI induced by lipopolysaccharide (LPS), ischemia reperfusion injury (IRI), folic acid overdose, or cisplatin overdose [40,41,42,43,44].