CHRM3 and neoplasm: Raufman et al. used an animal model employing Apcmin/+ mice to compare Chrm3+/+ mice (capable of M3R expression) to Chrm3-/- mice (not capable of M3R expression) and showed a 70% reduction in the number of tumors and an 81% reduction in tumor volume in the group that was not capable of M3R expression [28].