Recently, through advanced techniques such as gene and proteome analysis, many new biomarkers of CRC have been suggested in vitro, for example, immune checkpoint molecules such as OX40, receptors such as CXCR4 and CX3CR1 and kinases such as FJX1 (four-jointed box kinase 1), as well as micro-RNAs [10,13,15,16,17,18,19]. This evidence concerns the gene TNFRSF4 and colorectal carcinoma.