Meanwhile, although mAb are generally considered to be well tolerated in humans, some components may still be recognized by the recipient as foreign and subsequently lead to a violent immune response, such as acute anaphylactic (IgE-mediated) and anaphylactoid reactions against the mAb, serum sickness, tumor lysis syndrome, and cytokine release syndrome [27]. This evidence concerns the gene IGHE and Tumor Lysis Syndrome.