The binding of IFN-γ to its receptor on the surface of tumor cells leads to the significant upregulation of PD-L1 through the Janus kinase (JAK)1/JAK2- signal transducer and activators of the transcription (STAT)1/STAT2/STAT3- interferon regulatory factor (IRF) 1 axis [3]. Here, STAT3 is linked to neoplasm.