Histopathologic evaluation, gene expression, and computer-assisted immunohistologic studies have been performed on 19 skin biopsies from IBD (n = 17) and rheumatoid arthritis (n = 2) patients with new-onset inflammatory skin lesions during anti-TNF-α therapy [8], evidencing the new onset of psoriasiform, eczematous, and scalp anti-TNF-induced skin lesions. This evidence concerns the gene TNF and inflammatory bowel disease.