Interestingly, evidence supports a role for adipocytes-mediated release of EVs in the increased expression of VCAM-1 after being exposed to hypoxia and TNF-α, elements mimicking obesity conditions, and P-selectin and Glycoprotein Ib platelet subunit alpha (GPIbα) from circulating platelets directed to monocytes and neutrophiles, respectively [143,144,145]. The gene discussed is GP1BA; the disease is obesity due to melanocortin 4 receptor deficiency.