However, another study showed that partial CD4 clones isolated from the intestinal mucosa of eight patients at the early stage of intestinal BD produced IFN-γ and IL-17 (Th1/Th17 profile), suggesting that both Th1 and Th17 cells drive inflammation leading to mucosal damage in the early stage of intestinal BD [31]. The gene discussed is CD4; the disease is Behcet disease.