For intestinal BD, Ahn et al. revealed that extracellular high-mobility group Box 1 (HMGB1) expression, which could activate the release of cytokines and mediate inflammation in innate immunity, was significantly increased in BD patients with gastrointestinal involvement compared to BD patients without gastrointestinal involvement and healthy controls [61]. The gene discussed is HMGB1; the disease is Behcet disease.